Hemodilution is associated with underestimation of serum creatinine in cardiac surgery patients: a retrospective analysis

Abstract Background Fluid overload is related to the development and prognosis of cardiac surgery-associated acute kidney injury (CSA-AKI). The study investigate influence serum creatinine (SCr) corrected by fluid balance on patients with surgery. Methods A retrospective was conducted in 1334 who underwent elective surgery from January 1 December 31, 2015. Kidney Disease: Improving Global Outcomes (KDIGO) criteria for AKI were applied identify CSA-AKI. SCr measured every 24 h during ICU period accordingly adjusted cumulative balance. Changes SCr, defined as ?Crea, determined difference between before after adjustment All then divided into three groups: underestimation group (?Crea ? P 75 ), normal (P 25 < ?Crea ) overestimation ? ). Results incidence increased 29.5% 31.8% Patients showed prolonged length stay compared (3.2 [1.0–4.0] vs 2.1 [1.0–3.0] d, 0.001; 3.2 2.3 0.001). Length hospital mechanical ventilation dependent days significantly longer than ( Multivariate analysis age, baseline left ventricular ejection fraction independently associated creatinine. Conclusions Cumulative disturbs accurate measurement poor prognosis.